Down Regulation of Hepatic PPAR.ALPHA. Function by AhR Ligand

Down-Regulation of T Cell Function by Heat Shock-Induced Excretory Factor of Leishmania Major

Background: Despite demonstration of molecular and biochemical changes induced by heat shock on Leishmania, the immunological importance of such changes has not been elucidated.  Objective: Studying the effect of two excretory factors prepared under heat shock and ambient temperature from Leishmania major on Balb/c splenocytes function.  Methods: The parasites were cultured at 25°C and then sub...

Ligand-dependent receptor down-regulation

The kinetics of internalization, sequestration and metabolic degradation of atrial natriuretic factor (ANF)-receptor complex were studied in rat thoracic aortic smooth-muscle (RTASM) cells. These parameters were directly determined by measuring 125I-ANF binding to total, intracellular and cell-surface receptors. Pretreatment of cells with the lysosomotropic agent chloroquine and the energy depl...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

down-regulation of t cell function by heat shock-induced excretory factor of leishmania major

background: despite demonstration of molecular and biochemical changes induced by heat shock on leishmania , the immunological importance of such changes has not been elucidated.   objective: studying the effect of two excretory factors prepared under heat shock and ambient temperature from leishmania major on balb/c splenocytes function.   methods: the parasites were cultured at 25 ° c and the...

Transcriptional regulation of macrophage cholesterol trafficking by PPARalpha and LXR.

PPARs (peroxisome-proliferator-activated receptors) and LXRs (liver X receptors) are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Since the macrophage plays an important role in host defence and immuno-inflammatory pathologies, particular attention has been paid to the role of PPARs and LXRs in the control of macrophage ...